Contractures that have returnedDupuytren`s contracture can return regardless of the option you use. If your condition returns after treatment, non-surgical® XIAFLEX can be used again. Dupuytren`s contracture (pronounced “doo puh trenz”) is a progressive disease of the hand that causes thickening of the tissue just below the skin of the palm. An abnormal buildup of collagen thickens into a silky cord in the palm of the hand, slowly causing the fingers to curl to the point where they cannot be straightened. It is often confused with arthritis or other conditions. Over time, putting on the Dupuytren cord can significantly reduce the range of motion of your finger. The disease is hereditary and is also associated with smoking, vascular disease, epilepsy and diabetes. If the nodules or lumps are small, you may not need treatment.
However, when a rope forms, the affected fingers develop a contracture that can interfere with the proper functioning of the hand. Doctors may recommend treatment at this time with an injection of an enzyme or surgical excision, depending on the properties of the contracture. Learn how to perform post-treatment exercises for your hand Xiaflex treatment is likely to cause temporary swelling, bruising, bleeding, itching, and/or pain in the injected area and surrounding tissues. ® This usually resolves within a few days. Temporary swelling of the lymph nodes (glands) in the elbow or armpit may also be noted. Xiaflex is not suitable for all patients. Ask your doctor if this treatment is recommended for you. The most common side effects of XIAFLEX® for the treatment of Dupuytren`s contracture include swelling of the injection site or hand; bruising or bleeding at the injection site; pain or tenderness of the injection site or hand; swelling of the lymph nodes (glands) in the elbow or armpit; itching; breaks in the skin; redness or warmth of the skin; and armpit pain. If you are using this medicine to treat Dupuytren`s contracture, the medicine will be injected by your doctor into the tissue nodes (cord) of the affected hand. Your hand will be wrapped in soft gauze after the injection.
Limit hand movements and hold your hand elevated until bedtime. Do not try to stretch, curl or move the injected finger until your doctor tells you that everything is fine. Tell your doctor immediately if you experience numbness, tingling, or a feeling of needles and needles in your hand during the procedure. Are you considering treatment with XIAFLEX? ® The following steps can help you better understand what to expect. This patient had a cord that could be felt, causing contracture of the MP (metacarpophalangeal) joint of the left ring finger. The cable was injected with XIAFLEX® and 48 hours later a finger extension procedure was performed. Individual results may vary. Concrete examples of treatment with XIAFLEX include: ® *In 2 clinical trials, patients were asked to rate their satisfaction with treatment on day 90 as “very satisfied”, “somewhat satisfied”, “neither satisfied nor dissatisfied”, “somewhat dissatisfied or “very dissatisfied”. In October 2014, the FDA expanded the approval of XIAFLEX® for the treatment of up to two Dupuytren contracture joints in the same hand during a single treatment visit. .